If a dad or mum of your proband is thought to hold the pathogenic variant discovered during the proband, the danger to the sibs of inheriting the pathogenic variant is fifty%. As a consequence of diminished penetrance, sibs who inherit the pathogenic variant may or may not acquire aHUS (see https://air-handling-unit-ahu-hir87542.theisblog.com/32396098/ahu-hire-secrets