B-cells integrate antigen-specific signals transduced via the B-cell receptor (BCR) and antigen non-specific co-stimulatory signals provided by cytokines and CD40 ligation in order to produce IgG antibodies. Toll-like receptors (TLRs) also provide co-stimulation. but the requirement for TLRs to generate T-cell independent and T-cell dependent antigen specific antibody responses is deb... https://www.getpureroutine.com/quick-grab-blackmores-ache-relief-focus-60-tablets-supply-hot-grab/