Remark: Barbiturates could raise adverse effects, like respiratory depression, produced by harmful doses of TCAs. With therapeutic doses of TCAs, barbiturates boost metabolism and reduce blood concentrations of TCAs. pentobarbital will reduce the extent or outcome of elbasvir/grazoprevir by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. The therapeutic influen... https://eriche210pft7.bloggadores.com/profile