There exists a release of norepinephrine with the descending inhibitory bulbospinal neurons that binds to alpha-two-receptors in the dorsal horn to lower afferent soreness transmission and produce analgesia. Consequently, prescription drugs like clonidine that target alpha-2 receptors can influence the transmission of soreness. Applies to clonidine: oral pill, oral https://peters812muj6.wikievia.com/user